2024年6月2日，腐植酸科学与工程研究团队（即本团队）在化学类SCI期刊《Natural Product Research》杂志(3区，IF=2.2)在线发表了题为“The protective effects and potential mechanisms of fulvic acid against ethanol-induced gastric mucosal injury in mice（黄腐酸对乙醇致小鼠胃黏膜损伤的保护作用及其潜在机制）”的文章。第一通讯作者为张敉教授，第一作者为课题组已毕业硕士生陈崇莲同学。

摘要内容如下：Fulvic acid (Fa) is a kind of natural organic acids extracted from lignite, which is the active ingredient in Wujin oral liquid, a proprietary Chinese medicine used to treat gastric and duodenal ulcers. However, our understanding of the mechanisms of Fa remains limited. Currently, the protection of Fa and its mechanism were explored using the ethanol-induced gastric mucosal injury mouse model. the histopathological examinations showed Fas at three doses effectively reduced gastric congestion, oedema caused by ethanol, and prevented gastric epithelial cell fall-off. When compared to the model group, Fas reduced iL-1β and iL-6 levels in serum, as well as iL-1β, iL-6, tnF-α, and CoX-2 expression levels in tissue. Furthermore, Fas significantly inhibited p65, p38 mapK, and Erk1/2 phosphorylation in damaged gastric tissue. it was indicated Fa has good protection against ethanol-induced gastric mucosa injuries in mice and this effect was related to nF-κB and mapK signalling pathways. （黄腐酸是从褐煤中提取的一种天然有机酸，是乌金口服液的活性成分，乌金口服液是一种用于治疗胃和十二指肠溃疡的中药。然而，我们对黄腐酸的作用机制的理解仍然有限。本文通过乙醇诱导的胃黏膜损伤小鼠模型探索了黄腐酸的保护作用及其机制。组织病理学检查显示，三个剂量的黄腐酸能有效减少由乙醇引起的胃充血、水肿，并防止胃上皮细胞脱落。与模型组相比，黄腐酸降低了血清中IL-1β和IL-6的水平，以及组织中IL-1β、IL-6、TNF-α和COX-2的表达水平。此外，黄腐酸显著抑制了受损胃组织中p65、p38 MAPK和Erk1/2的磷酸化。这表明黄腐酸对小鼠乙醇诱导的胃黏膜损伤具有良好的保护作用，这种作用与NF-κB和MAPK信号通路有关。）

文章链接：https://www.tandfonline.com/doi/full/10.1080/14786419.2024.2360679